Factors causing an increase in the number of couples who cannot have children in society:
1. Advanced age marriages. As marriages shift to advanced ages, oocyte aging becomes the main problem in women. Advanced age marriages also increase the rate of diseases transmitted through sexual contact and the frequency of endometriosis, a disease specific to women whose frequency increases after the age of 30.
2. Smoking, alcohol and environmental toxic factors. More frequent and widespread use of smoking and alcohol and the increasing intensity of environmental toxic factors, increasing environmental pollution, and the increasing consumption of synthetic nutrients in the food supply are among the important factors affecting infertility.
3. Increase in the frequency of early menopause The frequency of early menopause is also increasing. The use of treatments introduced with medical and technological developments for the preservation of fertility remains at very low levels (for example: not using oocyte freezing and storage)
4. The accumulation of endometriosis towards the end of the productive years.
5. The increasing rate of male-related inability to have children.